Jump to content
Arizona IV Therapy Following the refill

The reading list

The experimental settings are the useful organising principle: cells, rats, people receiving NADH, and people receiving oral NMN.

Cell biology and replenishment

The review of NAD+ in ageing, metabolism and neurodegeneration and the review of NAD+ homeostasis in human health and disease give the replenishment question its biological setting. The review of NAD+/NADH in cellular function supplies the paired-form context.

For an actual experiment at the cell boundary, there is the metabolic-fate study in cultured human skin fibroblasts. The CD38 deletion study concerns mice. Their settings remain attached to the findings throughout this notebook.

IV experiments and human outcomes

The NAD+ heart-injury experiment concerns rats. The small double-blind NADH study and the open NADH study alongside conventional therapy concern Parkinson’s disease.

The oral NMN muscle-insulin-sensitivity trial and multicentre oral NMN trial provide the specific human outcomes on the trial ledger. The review of human ageing trials gives them a wider clinical context. The publication titles follow below.

  1. NAD⁺ in aging, metabolism, and neurodegeneration. ↗
  2. Metabolic fate of extracellular NAD in human skin fibroblasts. ↗
  3. Exogenous NAD(+) administration significantly protects against myocardial ischemia/reperfusion injury in rat model. ↗
  4. Treatment of Parkinson's disease with NADH. ↗
  5. Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis. ↗
  6. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism ↗
  7. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women ↗
  8. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial ↗
  9. NAD(+) precursor supplementation in human ageing: clinical evidence and challenges ↗
  10. NAD(+) homeostasis in human health and disease. ↗
  11. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. ↗